Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.

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Previous studies have shown that some tannins Salawu et febrivuga. Twenty four hours fasted rats were randomized into 6 groups of 5 rats each. Effects of the extract on ethanol-induced gastric ulceration Ethanol produced haemorrhagic gastric lesions mainly in the glandular segment of the stomach mucosa. Piroxicam-induced gastric ulceration The method described by Salawu et al.

Several plants containing high amounts of saponins have been shown to possess antiulcer activity in several experimental bioassays Yamahara et al, ; Yesilada and Takaish, ; Morikawa et al, probably acting as an activator of mucus membrane protective factors Saito et al.

Gastro-Protective Effect of Crossopteryx Febrifuga in Wistar Rats

Previous studies have shown that the methanolic stem bark extract of Crossopteryx febrifuga possesses significant analgesic and anti-inflammatory properties possibly mediated via Non-selective inhibition of cyclo-oxygenase pathways.

The method described by Salawu et al. The ulcer lesions were scored according to severity Larach and Malagelada, as follows:. Pharmacological studies of Panacis japonici Rhizoma. Introduction Nonsteroidal anti-inflammatory drugs NSAIDswhich act as non-selective cyclooxygenase COX inhibitors, are commonly used to treat pain and inflammation despite the risk of major upper gastrointestinal complications Venkova et al.


Acknowledgements The authors are grateful to the management of National Institute for Pharmaceutical Research and Development for provision of enabling environment and facilities used for the study.

West African Plants

Ulcer index UI defined as the severity of damage caused by an ulcer inducing agent was then calculated using the formula:. Histopathological studies further confirmed the extract’s mucosal protective effect in that it inhibited both piroxicam – and ethanol induced mucosal atrophy, infilteration by eosinophils and lymphoplasma cells in the wall glandular destruction, focal infiltration of inflammatory cells into mucosa areas.

Open in a separate window. Table 3 Results fegrifuga Histopathology examinations. These were then examined crossopreryx a consultant histopathologist. Abstract Preparations of Crossopteryx febrifuga Afzel. One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia. Effect of Crossopteryx febrifuga on ethanol-induced gastric ulceration in rats. Yesilada E, Takaishi Y.

The resultant mixture was filtered using Whatman filter paper No. Ethanol produced haemorrhagic gastric crosskpteryx mainly in the glandular segment of the stomach mucosa. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.

Afr J Pharm Pharmacol. Oxygen free radicals and lipid peroxidation Takeuchi et al. The studies were carried out following crossoptreyx principles of good laboratory practice and animal handling National Institutes of Health Guide for the Care and use for Laboratory animals; Publication No. Preparations of Crossopteryx febrifuga Afzel.


A saponin with anti-ulcerogenic effect from the flowers of Spartium junceum. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rats: Antiulcerogenic activity of aescine in different experimental models.

Crossopteryx febrifuga – Useful Tropical Plants

Traditional Complementary and Alternative Medicines J Med Plant Res. In conclusion this study illustrated the safety of Crossopteryx febrifuga in gastrointestinal tract when used as an antiinflammatory analgesic agent that could be developed for management of painful inflammatory disorders.

The number of deaths in each group within 24 h was recorded and the final LD 50 values were calculated as the geometric mean of the highest nonlethal dose with no deaths and the lowest lethal dose where deaths occurred. The phytochemical analyses carried out on methanolic stem bark extract of Crossopteryx febrifuga by Salawu et al.

Crossopteryx febrifuga

Crossopteyx by Santo et al. The data obtained in the test for acute toxicity suggest that the extract is moderately toxic Salawu et al. The oral median lethal dose LD 50 of the methanolic extract was determined in rats orally using Lorke’s method with modifications. The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats.

Chemical and Pharmaceutical Bulletin.